The latest version of the artificial intelligence (AI) model, AlphaFold 3, has been touted as a game-changer for drug discovery, because it can model the interaction of proteins with other molecules, including drugs. But a lack of examples of these interactions in the data underpinning AlphaFold ' hundreds of thousands of publicly available protein structures ' is holding the tool back for the applications that drug companies are most interested in, say scientists. A consortium of leading pharmaceutical companies announced plans today to make their own AlphaFold-3-inspired AI model using thousands of protein structures that are currently secreted away in company vaults. This is in addition to the more than 200,000 protein structures freely available in the Protein Data Bank (PDB). 'The data that's missing from the PDB is exactly the data that's present in our internal data,' says John Karanicolas, head of computational drug discovery at the pharma company AbbVie in Chicago, Illinois, and part of the effort, called the AI Structural Biology Consortium....

Whether you're hammering out intervals on the track, cruising a chatty social run, or lacing up for the long haul on the trails, a good pair of running shorts is mission critical. The best running shorts offer killer comfort and total freedom to move. They wick sweat, dry fast, and ward off unwanted chafe. The only problem' There's hundreds of styles from dozens of brands, and not all shorts are created equal. Don't fear, we've got you'and your downstairs'covered. As one of WIRED's running gear experts, I've logged hundreds of miles testing the latest shorts, and I'm here to help you sort the winners from those that come up, well erm, short. Here's my tried and tested picks for your bottom half. Be sure to check out our other sport and fitness buying guides, including the Best Running Shoes, the Best Running Underwear, the Best Treadmills, and the Best Merino Wool. Running shorts come in a wide variety of styles. Shorter shorts tend to be suited to shorter, faster runs, while two-in-one shorts and longer lengths are often used for longer distances and trails. You may find that there's a lot of crossover. Long inseams and superlight fabrics are now suitable for speed while offering good coverage. Even short shorts now offer storage for a phone or gels....

During his three presidential campaigns, Donald Trump promised to run the federal government as though it were a business. True to his word, upon retaking office, Trump put tech billionaire Elon Musk at the head of a new group in the executive branch called the Department of Government Efficiency. DOGE, as Musk's initiative is known, has so far fired, laid off or received resignations from tens of thousands of federal workers and says it has discovered large sums of wasted or fraudulently spent tax dollars. But even its questionable claim of saving US$65 billion is less than 1% of the $6.75 trillion the U.S. spent in the 2024 fiscal year, and a tiny fraction of the nation's cumulative debt of $36 trillion. Because Musk's operation has not been formalized by Congress, DOGE's indiscriminate cuts also raise troubling constitutional questions and may be illegal. Before they go too far trying to run the government like a business, Trump and his advisors may want to consider the very different example of the nation's first chief executive while he was in office....

Like many Americans lately, I am seized with curiosity about who is actually running the government of the United States. For that reason, I watched Sean Hannity's Fox News interview tonight with President Donald Trump and Elon Musk. But I am still not sure who's in charge. If there is a headline from the interview, it is that the president of the United States feels that he requires the services of a multi-billionaire to enforce his executive orders. Trump complained that he would write these 'beautiful' executive orders, that would then languish in administrative limbo. Musk, for his part, explained how the president is the embodiment of the nation and that resisting his orders is the same as thwarting the will of the people. Hannity, of course, enthusiastically supported all of this whining about how hard it is to govern a superpower. The goal of the interview, I assume, was to calm some of the waters around Trump's relationship with Musk, and especially to present Musk as just another patriotic American who is only trying to help out his government in a time of crisis. Hannity deplored how shamefully the richest man in the world is being treated despite trying to create technologies to 'help the blind to see.' Trump and Musk bemoaned how the world is trying to drive them apart, but affirmed that they like each other very much. 'I wanted to find somebody smarter than him,' Trump said in one of his classic insult-praise combination punches, 'but I couldn't do it.'...

Secretary of Defense Pete Hegseth has been busy. Over the past few weeks, he's been rooting out programs and language related to diversity, equity, and inclusion. The U.S. military is dutifully following his lead: West Point no longer supports those ostensibly suspicious organizations such as the Native American Heritage Forum and the Latin Cultural Club, and the Army Recruiting Command has ended its long partnership with the Black Engineer of the Year Awards. The new Pentagon boss also zeroed in on the pressing task of renaming Fort Liberty back to Fort Bragg, though it's not exactly a reversal; Hegseth ordered that the base now honor a World War II hero named Roland Bragg (a private first class who won the Silver Star and a Purple Heart at the Battle of the Bulge) instead of the odious Confederate General Braxton Bragg, for whom it was named in 1918. This change is little more than a clumsy stunt, one that manages to insult a loyal PFC while resurrecting the traitorous general'almost certainly after searching for a hero named Bragg, just so people could use the old name with a wink and a chuckle....

Super Bowl weekend is here with the Philadelphia Eagles set to take on the Kansas City Chiefs in New Orleans on Sunday evening. While many folks tune in to the Super Bowl for the actual football, others do so for the halftime performance, and some tune in just for the ads. The ad roster this year includes many of the names one comes to expect to see at the Super Bowl, from beer companies like Budweiser and Coors to savory snack companies like Doritos. We'll also see some ads from a handful of startups. It might seem odd for a startup, especially one with limited cash flow and venture capital investors, to spend the millions required to grab an ad slot at the big game. But sometimes the marketing strategy can pay off. Bernard Schmitt, a professor at Columbia Business School focused on marketing, told TechCrunch ahead of last year's Super Bowl that while the Super Bowl is a big audience to get in front of, it's often too broad to be an effective approach for many companies. But he added that it does allow a startup to flaunt their prowess, which can help them stand out....

The explosive improvement in artificial intelligence (AI) technology has largely been driven by making neural networks bigger and training them on more data. But experts suggest that the developers of these systems may soon run out of data to train their models. As a result, teams are taking new approaches, such as searching for other unconventional data sources, or generating new data to train their AIs....

Running is a sport packed full of lessons and motivational tropes. You are stronger than you think, routines build consistency, and consistency leads to results. Getting out the front door is often the hardest part of all. But no matter how far, or how frequently you run, one things is almost guarantee. If you don't prepare, your softest and most delicate bits will suffer from chaffing. Sometimes you only find out the full extent of the chafe when water hits your painful parts in the post-run shower, or you finish a run only to find you've bled all over your favorite top. Thankfully, it doesn't have to be that way. With the running gear and a bit of carefully applied, specifically engineered lube, you need never suffer the friction burns again. To help you beat the dreaded skin burn, I've rounded up the best running underwear for cruising in comfort, along with the best anti-chafe balms and nipple protectors. Be sure to check out our other sport and fitness buying guides, including our Best Running Gear, Best Trail Running Shoes, the Best Rain Jackets and Hiking Gear 101....