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Organizations should continually aspire to 'meet the needs of the present without compromising the ability of future generations to meet their own needs'. This is the essence of the sustainability approach and of sustainability management in organization and businesses. Sustainability is a perfect system concern which involves stakeholders of all kinds, deals with the entire lifecycle of products and systems, incorporates economic, environmental and social considerations in management and engineering, and entails new risks and opportunities to be managed by the organizations. We propose an integrated model for the design and management for sustainability in business. This model relies on some key Systems Engineering methodologies and Quality Management approaches. Also described is some of our experience with sustainability progress in both our companies ' RAFAEL and Carlsberg'Srbija.