Culminating 25 years of research, MIT, Harvard University, and Yale University scientists and collaborators have unveiled a comprehensive atlas of human tyrosine kinases ' enzymes that regulate a wide variety of cellular activities ' and their binding sites. The addition of tyrosine kinases to a previously published dataset from the same group now completes a free, publicly available atlas of all human kinases and their specific binding sites on proteins, which together orchestrate fundamental cell processes such as growth, cell division, and metabolism. Now, researchers can use data from mass spectrometry, a common laboratory technique, to identify the kinases involved in normal and dysregulated cell signaling in human tissue, such as during inflammation or cancer progression. 'I am most excited about being able to apply this to individual patients' tumors and learn about the signaling states of cancer and heterogeneity of that signaling,' says Michael Yaffe, who is the David H....
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