A decade after scientists in The Picower Institute for Learning and Memory at MIT first began testing whether sensory stimulation of the brain's 40Hz 'gamma' frequency rhythms could treat Alzheimer's disease in mice, a growing evidence base supporting the idea that it can improve brain health ' in humans as well as animals ' has emerged from the work of labs all over the world. A new open-access review article in PLOS Biology describes the state of research so far and presents some of the fundamental and clinical questions at the forefront of the noninvasive gamma stimulation now. 'As we've made all our observations, many other people in the field have published results that are very consistent,' says Li-Huei Tsai, Picower professor of neuroscience at MIT, director of MIT's Aging Brain Initiative, and senior author of the new review, with postdoc Jung Park. 'People have used many different ways to induce gamma including sensory stimulation, transcranial alternating current...
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