Despite the profound human, social and economic costs of alcohol abuse, existing treatments have failed to provide meaningful relief. Excessive alcohol consumption remains a leading cause of death and disability worldwide. In the U.S. alone, 16.4 million people age 12 and older reported binge drinking on five or more days in the past month. Although there are several drugs available to those seeking to stop or lower their alcohol consumption, their effectiveness is limited, and they often have significant side effects. Over the past three decades, efforts to treat excessive drinking have focused primarily on developing drugs that target proteins that can control how neurons respond to stimuli. Because these proteins are present in almost every neuron throughout the brain, the drugs also affect neurons that aren't directly responsible for regulating alcohol's effects. This often leads to unwanted side effects like headache, fatigue, drowsiness or insomnia. In my work as a...
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