Philosophy of science is the branch of philosophy concerned with the foundations, methods, and implications of science. Amongst its central questions are the difference between science and non-science, the reliability of scientific theories, and the ultimate purpose and meaning of science as a human endeavour. Philosophy of science focuses on metaphysical, epistemic and semantic aspects of scientific practice, and overlaps with metaphysics, ontology, logic, and epistemology, for example, when it explores the relationship between science and the concept of truth. Philosophy of science is both a theoretical and empirical discipline, relying on philosophical theorising as well as meta-studies of scientific practice. Ethical issues such as bioethics and scientific misconduct are often considered ethics or science studies rather than the philosophy of science. Many of the central problems concerned with the philosophy of science lack contemporary consensus, including whether science can infer truth about unobservable entities and whether inductive reasoning can be justified as yielding definite scientific knowledge. Philosophers of science also consider philosophical problems within particular sciences (such as biology, physics and social sciences such as economics and psychology). Some philosophers of science also use contemporary results in science to reach conclusions about philosophy itself. While philosophical thought pertaining to science dates back at least to the time of Aristotle, general philosophy of science emerged as a distinct discipline only in the 20th century following the logical positivist movement, which aimed to formulate criteria for ensuring all philosophical statements' meaningfulness and objectively assessing them. Karl Popper criticized logical positivism and helped establish a modern set of standards for scientific methodology. Thomas Kuhn's 1962 book The Structure of Scientific Revolutions was also formative, challenging the view of scientific progress as the steady, cumulative acquisition of knowledge based on a fixed method of systematic experimentation and instead of arguing that any progress is relative to a "paradigm", the set of questions, concepts, and practices that define a scientific discipline in a particular historical period. Subsequently, the coherentist approach to science, in which a theory is validated if it makes sense of observations as part of a coherent whole, became prominent due to W. V. Quine and others. Some thinkers such as Stephen Jay Gould seek to ground science in axiomatic assumptions, such as the uniformity of nature. A vocal minority of philosophers, and Paul Feyerabend in particular, argue against the existence of the "scientific method", so all approaches to science should be allowed, including explicitly supernatural ones. Another approach to thinking about science involves studying how knowledge is created from a sociological perspective, an approach represented by scholars like David Bloor and Barry Barnes. Finally, a tradition in continental philosophy approaches science from the perspective of a rigorous analysis of human experience. Philosophies of the particular sciences range from questions about the nature of time raised by Einstein's general relativity, to the implications of economics for public policy. A central theme is whether the terms of one scientific theory can be intra- or intertheoretically reduced to the terms of another. Can chemistry be reduced to physics, or can sociology be reduced to individual psychology' The general questions of philosophy of science also arise with greater specificity in some particular sciences. For instance, the question of the validity of scientific reasoning is seen in a different guise in the foundations of statistics. The question of what counts as science and what should be excluded arises as a life-or-death matter in the philosophy of medicine. Additionally, the philosophies of biology, psychology, and the social sciences explore whether the scientific studies of human nature can achieve objectivity or are inevitably shaped by values and by social relations.